Autoimmune Disease in Standard Poodles
12/27/2019
2 Comments
Vaccines and Immunity.
Indeed, time and again, we know that giving humans and animals – who already have an immune deficiency, autoimmune disease or immune dysfunction – a vaccine may, in fact, cause the disease it is trying to prevent. The debate remains controversial. Can vaccines trigger immune-mediated diseases in the general population or in patients with PIDD? While young babies, puppies, ponies or kittens exposed frequently to polyvalent vaccine antigens may not demonstrate overt adverse effects, their relatively immature immune systems may be temporarily or more permanently harmed from such antigenic exposures. Consequences in later life may be the increased susceptibility to chronic debilitating diseases. Some veterinarians trace the increasing current problems with allergic and immunological diseases to the introduction of MLV vaccines some 20 years ago. While other environmental factors no doubt have a contributing role, the introduction of these vaccine antigens and their environmental shedding may provide the final insult that exceeds the immunological tolerance threshold of some individuals. From my 50-year perspective as a veterinary immunologist and hematologist which included my being the Executive Secretary of the New York State Council on Human Blood and Transfusion Services, vaccines can trigger these diseases. The caveat is that affected individuals must first have the genetic predisposition to have vaccine-associated disorders. Overall, we have to remember:
As I stated, this is multifactorial. In my opinion, why vaccinate an animal or human that has sufficient immunity to a disease, if the risk of infection is low and the symptoms are not life-threatening, particularly if we know that adverse effects can happen. TreatmentInherently, we want to boost the immune system of an individual with an immunodeficiency. However, during an immune-mediated or sensitivity flare up, we want to “suppress” or down-regulate that portion of the immune system. This is an important point to make: people often assume that immune support or boosters will correct an immune-mediated disease. However, this may actually exacerbate the problem. It is quite a balancing act for all conventional and holistic medical professionals, because we want to boost one side of the immune system but down-regulate the other side. The good news though is that standard conventional treatments such as corticosteroids and other immune suppressant drugs used for immunologic disorders can often be replaced or augmented with holistic alternatives and homeopathic remedies. GlossaryImmune Disorder: An umbrella phrase for dysfunction of the immune system which can be either overactive or underactive. Immune-Mediated (Autoimmune) disease: A disease that results when the body’s immune system reacts against the individual’s own tissue(s). Immunocompromised: A state in which an individual’s immune system is absent, weakened or dysfunctional. Immunodeficiency: A state of either a congenital (present at birth) or an acquired (secondary) abnormality of the immune system that prevents adequate immune responsiveness. Immunomodulator: A chemical agent, drug, or other substance that modifies the immune response or the functioning of the immune system. Immunosuppression: Suppression of natural immune responses. Vaccine: A substance that contains components from an infectious organism or other antigen (protein) which stimulates an immune response in order to protect against subsequent exposure to that organism or antigen. W. Jean Dodds, DVM Hemopet / NutriScan 11561 Salinaz Avenue Garden Grove, CA 92843 References Arason, G. J., Jorgensen, G. H. and Ludviksson, B. R. (2010), “Primary Immunodeficiency and Autoimmunity: Lessons From Human Diseases”. Scandinavian Journal of Immunology, 71: 317–328. doi: 10.1111/j.1365-3083.2010.02386.x “Disorders of the Immune System." National Institute of Allergy and Infectious Diseases. National Institutes of Health, 17 Jan. 2014. Web. 24 July 2016. http://www.niaid.nih.gov/topics/immuneSystem/Pages/immuneDisorders.aspx. Dodds WJ. Genetically based immune disorders: Autoimmune diseases, Parts 1-3. Vet Pract STAFF, 4 (1, 2, and 3): 8-10, 1, 26-31, 35-37, 1992. Dodds WJ. Immune deficiency diseases: Genetically based immune disorders, Part 4. Vet Pract STAFF, 4 (5): 19-21, 1992. Dodds WJ. Vaccine-related issues, Chapter 40. In: Complementary and Alternative Veterinary Medicine. Mosby, St. Louis, 1997; pp 701-712. Dodds WJ. More bumps on the vaccine road. Adv Vet Med 41:715-732, 1999. Dodds WJ. Vaccination protocols for dogs predisposed to vaccine reactions. J Am An Hosp Assoc 38:1-4, 2001. Hustead DR, Carpenter T, Sawyer DC, et al. Vaccination issues of concern to practitioners. J Am Vet Med Assoc 214: 1000-1002, 1999. "IDSA Releases Recommendations on Vaccinations in Immunocompromised Patients." American Family Physician 90.9 (2014): 664-66. Web. 24 July 2016. http://www.aafp.org/afp/2014/1101/p664.html. Offit, Paul A., and Charles J. Hackett. "Addressing Parents’ Concerns: Do Vaccines Cause Allergic or Autoimmune Diseases?" Pediatrics 111.3 (2003): n. pag. AAP Gateway, Mar. 2003. Web. 24 July 2016. http://pediatrics.aappublications.org/content/111/3/653. "Parasites - Cryptosporidium.” Centers for Disease Control and Prevention, n.d. Web. 24 July 2016. http://www.cdc.gov/parasites/crypto/gen_info/infect_ic.html. “Patient & Family Handbook.” Immune Deficiency Foundation, 2013. Web. 24 July 2016. http://primaryimmune.org/patient-family-handbook/. Schultz RD. Current and future canine and feline vaccination programs. Vet Med 93:233-254,1998. Sleasman, JW. “The Association between Immunodeficiency and the Development of Autoimmune Disease." Advances in Dental Research10.1 (1996): 57-61. National Center for Biotechnology Information. U.S. National Library of Medicine. Web. 24 July 2016. http://www.ncbi.nlm.nih.gov/pubmed/8934926. Smith CA. Are we vaccinating too much? J Am Vet Med Assoc 207:421-425, 1995. Tizard I. Risks associated with use of live vaccines. J Am Vet Med Assoc 196:1851-1858, 1990. Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 213: 54-60, 1998. Tizard IR, Schubot RM. Veterinary Immunology: An Introduction, 6th ed. WB Saunders, Philadelphia, 2000, 480 pp. Tuano, Karen S. et al. “Food Allergy in Patients with Primary Immunodeficiency Diseases: Prevalence within the US Immunodeficiency Network (USIDNET).” The Journal of allergy and clinical immunology 135.1 (2015): 273–275. PMC. Web. 24 July 2016. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324505/ Twark L, Dodds WJ. Clinical application of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. J Am Vet Med Assoc 217:1-4, 2000. See more at: https://frenchstandardpoodles.com/
2 Comments
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